尖峰神经网络（SNN）提供了一个新的计算范式，能够高度平行，实时处理。光子设备是设计与SNN计算范式相匹配的高带宽，平行体系结构的理想选择。 CMO和光子元件的协整允许将低损耗的光子设备与模拟电子设备结合使用，以更大的非线性计算元件的灵活性。因此，我们在整体硅光子学（SIPH）过程上设计和模拟了光电尖峰神经元电路，该过程复制了超出泄漏的集成和火（LIF）之外有用的尖峰行为。此外，我们探索了两种学习算法，具有使用Mach-Zehnder干涉法（MZI）网格作为突触互连的片上学习的潜力。实验证明了随机反向传播（RPB）的变体，并在简单分类任务上与标准线性回归的性能相匹配。同时，将对比性HEBBIAN学习（CHL）规则应用于由MZI网格组成的模拟神经网络，以进行随机输入输出映射任务。受CHL训练的MZI网络的性能比随机猜测更好，但不符合理想神经网络的性能（没有MZI网格施加的约束）。通过这些努力，我们证明了协调的CMO和SIPH技术非常适合可扩展的SNN计算体系结构的设计。

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

对脑外伤（TBI）患者的准确预后很难为治疗，患者管理和长期护理提供信息至关重要。年龄，运动和学生反应性，缺氧和低血压以及计算机断层扫描（CT）的放射学发现等患者特征已被确定为TBI结果预测的重要变量。 CT是临床实践中选择的急性成像方式，因为其获取速度和广泛的可用性。但是，这种方式主要用于定性和半定量评估，例如马歇尔评分系统，该系统容易受到主观性和人为错误。这项工作探讨了使用最先进的，深度学习的TBI病变分割方法从常规获得的医院入院CT扫描中提取的成像生物标志物的预测能力。我们使用病变体积和相应的病变统计作为扩展TBI结果预测模型的输入。我们将我们提出的功能的预测能力与马歇尔分数进行比较，并与经典的TBI生物标志物配对。我们发现，在预测不利的TBI结果时，自动提取的定量CT功能的性能与Marshall分数相似或更好。利用自动地图集对齐，我们还确定额叶外病变是不良预后的重要指标。我们的工作可能有助于更好地理解TBI，并提供有关如何使用自动化神经影像分析来改善TBI后预测的新见解。

尽管电子健康记录是生物医学研究的丰富数据来源，但这些系统并未在医疗环境中统一地实施，并且由于医疗保健碎片化和孤立的电子健康记录之间缺乏互操作性，可能缺少大量数据。考虑到缺少数据的案例的删除可能会在随后的分析中引起严重的偏见，因此，一些作者更喜欢采用多重插补策略来恢复缺失的信息。不幸的是，尽管几项文献作品已经通过使用现在可以自由研究的任何不同的多个归档算法记录了有希望的结果，但尚无共识，MI算法效果最好。除了选择MI策略之外，归纳算法及其应用程序设置的选择也至关重要且具有挑战性。在本文中，受鲁宾和范布伦的开创性作品的启发，我们提出了一个方法学框架，可以应用于评估和比较多种多个插补技术，旨在选择用于计算临床研究工作中最有效的推断。我们的框架已被应用于验证和扩展较大的队列，这是我们在先前的文献研究中提出的结果，我们在其中评估了关键患者的描述符和Covid-19的影响在2型糖尿病患者中的影响，其数据为2型糖尿病，其数据为2型糖尿病由国家共同队列合作飞地提供。

像汤普森采样等多武装强盗算法可用于进行自适应实验，其中最大化奖励意味着数据用于逐步为更多参与者分配更有效的武器。这些转让策略增加了统计假设试验的风险，鉴定武器之间的差异，当没有一个时，并且在真正是一个是一个时，武器的差异存在差异。我们为2臂实验仿真，探讨了两种算法，这些算法结合了统计分析的均匀随机化的益处，具有通过Thompson采样（TS）实现的奖励最大化的益处。首先，前两种汤普森采样增加了固定量的均匀随机分配（UR）随时间均匀传播。二，一种新的启发式算法，称为TS Postdiff（差异后概率）。 Ts Postdiff采用贝叶斯方法来混合TS和UR：使用UR分配分配参与者的概率是后部概率，即两个臂之间的差异是“小”（低于某个阈值），允许在存在时探索更多的探索很少或没有奖励获得。我们发现TS PostDiff方法跨多种效果大小进行良好，因此不需要根据真实效果大小的猜测进行调整。

A "heart attack" or myocardial infarction (MI), occurs when an artery supplying blood to the heart is abruptly occluded. The "gold standard" method for imaging MI is Cardiovascular Magnetic Resonance Imaging (MRI), with intravenously administered gadolinium-based contrast (late gadolinium enhancement). However, no "gold standard" fully automated method for the quantification of MI exists. In this work, we propose an end-to-end fully automatic system (MyI-Net) for the detection and quantification of MI in MRI images. This has the potential to reduce the uncertainty due to the technical variability across labs and inherent problems of the data and labels. Our system consists of four processing stages designed to maintain the flow of information across scales. First, features from raw MRI images are generated using feature extractors built on ResNet and MoblieNet architectures. This is followed by the Atrous Spatial Pyramid Pooling (ASPP) to produce spatial information at different scales to preserve more image context. High-level features from ASPP and initial low-level features are concatenated at the third stage and then passed to the fourth stage where spatial information is recovered via up-sampling to produce final image segmentation output into: i) background, ii) heart muscle, iii) blood and iv) scar areas. New models were compared with state-of-art models and manual quantification. Our models showed favorable performance in global segmentation and scar tissue detection relative to state-of-the-art work, including a four-fold better performance in matching scar pixels to contours produced by clinicians.

Three main points: 1. Data Science (DS) will be increasingly important to heliophysics; 2. Methods of heliophysics science discovery will continually evolve, requiring the use of learning technologies [e.g., machine learning (ML)] that are applied rigorously and that are capable of supporting discovery; and 3. To grow with the pace of data, technology, and workforce changes, heliophysics requires a new approach to the representation of knowledge.

Managing novelty in perception-based human activity recognition (HAR) is critical in realistic settings to improve task performance over time and ensure solution generalization outside of prior seen samples. Novelty manifests in HAR as unseen samples, activities, objects, environments, and sensor changes, among other ways. Novelty may be task-relevant, such as a new class or new features, or task-irrelevant resulting in nuisance novelty, such as never before seen noise, blur, or distorted video recordings. To perform HAR optimally, algorithmic solutions must be tolerant to nuisance novelty, and learn over time in the face of novelty. This paper 1) formalizes the definition of novelty in HAR building upon the prior definition of novelty in classification tasks, 2) proposes an incremental open world learning (OWL) protocol and applies it to the Kinetics datasets to generate a new benchmark KOWL-718, 3) analyzes the performance of current state-of-the-art HAR models when novelty is introduced over time, 4) provides a containerized and packaged pipeline for reproducing the OWL protocol and for modifying for any future updates to Kinetics. The experimental analysis includes an ablation study of how the different models perform under various conditions as annotated by Kinetics-AVA. The protocol as an algorithm for reproducing experiments using the KOWL-718 benchmark will be publicly released with code and containers at https://github.com/prijatelj/human-activity-recognition-in-an-open-world. The code may be used to analyze different annotations and subsets of the Kinetics datasets in an incremental open world fashion, as well as be extended as further updates to Kinetics are released.

The availability of frequent and cost-free satellite images is in growing demand in the research world. Such satellite constellations as Landsat 8 and Sentinel-2 provide a massive amount of valuable data daily. However, the discrepancy in the sensors' characteristics of these satellites makes it senseless to use a segmentation model trained on either dataset and applied to another, which is why domain adaptation techniques have recently become an active research area in remote sensing. In this paper, an experiment of domain adaptation through style-transferring is conducted using the HRSemI2I model to narrow the sensor discrepancy between Landsat 8 and Sentinel-2. This paper's main contribution is analyzing the expediency of that approach by comparing the results of segmentation using domain-adapted images with those without adaptation. The HRSemI2I model, adjusted to work with 6-band imagery, shows significant intersection-over-union performance improvement for both mean and per class metrics. A second contribution is providing different schemes of generalization between two label schemes - NALCMS 2015 and CORINE. The first scheme is standardization through higher-level land cover classes, and the second is through harmonization validation in the field.

Microswimmers can acquire information on the surrounding fluid by sensing mechanical queues. They can then navigate in response to these signals. We analyse this navigation by combining deep reinforcement learning with direct numerical simulations to resolve the hydrodynamics. We study how local and non-local information can be used to train a swimmer to achieve particular swimming tasks in a non-uniform flow field, in particular a zig-zag shear flow. The swimming tasks are (1) learning how to swim in the vorticity direction, (2) the shear-gradient direction, and (3) the shear flow direction. We find that access to lab frame information on the swimmer's instantaneous orientation is all that is required in order to reach the optimal policy for (1,2). However, information on both the translational and rotational velocities seem to be required to achieve (3). Inspired by biological microorganisms we also consider the case where the swimmers sense local information, i.e. surface hydrodynamic forces, together with a signal direction. This might correspond to gravity or, for micro-organisms with light sensors, a light source. In this case, we show that the swimmer can reach a comparable level of performance as a swimmer with access to lab frame variables. We also analyse the role of different swimming modes, i.e. pusher, puller, and neutral swimmers.